Plasminogen activator inhibitor-1: The double-edged sword in apoptosis

Plasminogen activator inhibitor-1: the double-edged sword in apoptosis.

Plasminogen activator inhibitor type-1 (PAI-1) is a multi-functional protein. It is a fast-acting inhibitor of plasminogen activators; urokinase-plasminogen activator and tissue type plasminogen activator, and also plays an important role in regulating cell proliferation, adhesion, migration, and signal transduction pathways. These biological events are important processes during angiogenesis a...

Double-edged Sword 1 The Double-edged Sword of a Moral State of Mind

A Double-Edged Sword?

The enormous benefits of inhibition of ACE demonstrate that manipulation of the metabolism of peptide hormones is a valuable therapeutic strategy for cardiovascular disease. Recent attempts to expand these benefits have combined ACE inhibition with inhibition of other peptidases such as neutral endopeptidase (NEP) in a single molecule, a strategy known as vasopeptidase inhibition. NEP metaboliz...

Sunscreen- The Double Edged Sword

Sunscreens have long being recognized as substances to provide effective protection against the detrimental effects of solar radiation. The deleterious effects of sun exposure can be either acute (e.g. sunburn and drug-induced photo toxicity) or chronic (potential long-term risks of repeated sun exposures like solar elastosis, keratoses, induction of skin cancers, and alteration of immune respo...

Double-edged sword.

chemotherapy or HIV. Therefore, flight attendants and others say that airplane cabin air should be held to higher standards than workplaces. Pressure from passengers may be a major contributing factor in encouraging airlines to increase fresh air. In the August issue of Consumer Reports, airlines were ranked according to levels of carbon dioxide in airplane cabins and criticized for the low amo...